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In optimal experimental design, the objective is to select a limited set of experiments that maximizes information about unknown model parameters based on factor levels. This work addresses the generalized D-optimal design problem, allowing for nonlinear relationships in factor levels. We develop scalable algorithms suitable for cases where the number of candidate experiments grows exponentially with the factor dimension, focusing on both first- and second-order models under design constraints. Particularly, our approach integrates convex relaxation with pricing-based local search techniques, which can provide upper bounds and performance guarantees. Unlike traditional local search methods, such as the ``Fedorov exchange" and its variants, our method effectively accommodates arbitrary side constraints in the design space. Furthermore, it yields both a feasible solution and an upper bound on the optimal value derived from the convex relaxation. Numerical results highlight the efficiency and scalability of our algorithms, demonstrating superior performance compared to the state-of-the-art commercial software, \texttt{JMP}. 

We consider the Max-3-Section problem, where we are given an undirected graph G = (V, E) equipped with non-negative edge weights w : E → R+ and the goal is to find a partition of V into three equisized parts while maximizing the total weight of edges crossing between different parts. Max-3-Section is closely related to other well-studied graph partitioning problems, e.g., Max-Cut, Max-3-Cut, and Max-Bisection. We present a polynomial time algorithm achieving an approximation of 0.795, that improves upon the previous best known approximation of 0.673. The requirement of multiple parts that have equal sizes renders Max-3-Section much harder to cope with compared to, e.g., Max-Bisection. We show a new algorithm that combines the existing approach of Lassere hierarchy along with a random cut strategy that suffices to give our result.